Messi remains a major doubt due to a muscle injury that has kept him out for several matches. First-choice goalkeeper Drake Callender is also injured and will miss the game.
The midfield will be anchored by Sergio Busquets and De Paul, while Luis Suárez is expected to spearhead the attack.
For the Galaxy, Riqui Puig will miss out due to a knee injury. In his absence, Marco Reus, Edwin Cerrillo, and Diego Fagundez are expected to control the midfield.
Predicted Lineups
Inter Miami:
Ustari; Allen, Falcon, Alba, Fray; Busquets, Bright, Allende, De Paul, Segovia; Suarez
LA Galaxy:
Micovic; Aude, Zanka, Yoshida, Cuevas; Fagundez, Cerrillo, Reus; Pec, Nascimento, Paintsil