Meanwhile, Maximiliano Falcon is already ruled out due to yellow card accumulation.
If Messi plays, he will be aiming for another brace, which would put him ahead of Nashville’s Sam Surridge in the MLS Golden Boot race — both are currently tied with 18 goals.
Inter Miami remain without several injured players, including Noah Allen, Drake Callender, Ian Fray, Oscar Ustari, Baltasar Rodriguez, and Allen Obando.
On the Cincinnati side, Kevin Denkey and Obinna Nwobodo are sidelined due to leg injuries, while Yuya Kubo is out with an ankle issue.
Evander, who had scored in five consecutive matches prior to last weekend, will be looking to regain his form — especially after netting twice against Miami in their last meeting.
Predicted Inter Miami Starting XI:
Novo; Weigandt, Aviles, Lujan, Alba; Allende, Redondo, Busquets, Segovia; Messi, Suarez
Predicted FC Cincinnati Starting XI:
Celentano; Robinson, Miazga, Engel; Powell, Bucha, Anunga, Orellano; Evander, Kamara, Valenzuela