For City, Rico Lewis is suspended following his controversial red card against Wydad and subsequent two-match ban.
Claudio Echeverri is a doubt after twisting his ankle, while Mateo Kovacic is still recovering from Achilles surgery.
However, Ballon d’Or winner Rodri, who has featured twice as a substitute, may be ready for his first start after nine months out with an ACL injury.
Summer signings Tijjani Reijnders, Rayan Ait-Nouri, and Rayan Cherki are all in contention to start, alongside key players Ederson, Ruben Dias, Phil Foden, Savinho, and Omar Marmoush, who are pushing for recalls.
Predicted Starting Lineups
Juventus (3-4-3):
Di Gregorio; Savona, Kelly, Kalulu; Costa, Thuram, McKennie, Cambiaso; Conceicao, Yildiz; Kolo Muani
Manchester City (4-2-3-1):
Ederson; Nunes, Dias, Gvardiol, Ait-Nouri; Rodri, Reijnders; Savinho, Foden, Marmoush; Haaland