This presents a golden opportunity for the Black and Gold to register their first points of the tournament.
Veteran goalkeeper Hugo Lloris will remain between the sticks, with Olivier Giroud leading the line up front.
Denis Bouanga is also set to feature in the attacking third as LAFC aim to give their fans something to cheer about in their last outing.
On the other side, Flamengo will make wholesale changes from the Chelsea clash. Pedro, Everton, and Alex Sandro are expected to start, while Jorginho is likely to be rested ahead of the Round of 16.
Allan could step into midfield as a replacement, and young winger Matheus Gonçalves may get a start on the right flank. Gonzalo Plata and Gerson are among those anticipated to be benched from the opening whistle.
Predicted LAFC Starting XI:
Lloris; Palencia, Long, Segura, Hollingshead; Delgado, Igor, Tillman; Martinez, Giroud, Bouanga
Predicted Flamengo Starting XI:
Rossi; Wesley, Danilo, Pereira, Sandro; Allan, Pulgar; Matheus, Everton, Araujo; Pedro